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There is a big difference between hormetic cortisol spikes (exercise, fasting, cold) and chronic cortisol drip (financial stress, bad sleep, anxiety) Hormetic stress: quick spike then shutoff, changes receptor density in a beneficial direction

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Clinical manifestations of ICANS included, but were not limited to, confusional state, lethargy, tremor, dysgraphia, aphasia, and non-convulsive status epilepticus